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Login to my bpac. Remember me. Dermatology Genitourinary system male Gynaecology and urinary tract disorders female Medicine indications Oncology. Imiquimod cream Aldara for genital warts and basal cell carcinoma Imiquimod enhances the immune response to viral infections and tumours by stimulating the immune system to release interferon and other cytokines.
In this article Imiquimod is an immune response modifier Therapeutic uses of imiquimod Adverse effects References In this article. Imiquimod is an immune response modifier Imiquimod cream is now funded on special authority for the treatment of genital warts and superficial basal cell carcinoma The special authority criteria are: Either: The patient has external anogenital warts and podophyllotoxin has been tried and failed or is contraindicated ; or The patient has external anogenital warts and podophyllotoxin is unable to be applied accurately to the site; or The patient has confirmed superficial basal cell carcinoma where other standard treatments, including surgical excision, are contraindicated or inappropriate.
Superficial basal cell carcinoma Surgical excision remains the first line therapy for superficial basal cell carcinoma. Table 1. Dosing for imiquimod cream 2 Imiquimod cream should be applied with the fingertip and rubbed into the affected area until the cream vanishes Wash hands before and after application The treatment should be washed off with mild soap and water after six to ten hours Local inflammatory reactions may occur.
If severe, stop treatment for a few days and then resume once the reaction subsides. Rest periods are considered part of the treatment and the treatment period does not need to be extended to make up for missed doses Each condition has a different dosing frequency: Condition Dose Comment Superficial basal cell carcinoma The patient should apply imiquimod cream once daily at bedtime for five consecutive days per week e.
Monday to Friday for six weeks. Sufficient cream should be applied to cover the area and 1cm of skin surrounding the lesion Genital warts The patient should apply imiquimod cream once daily at bedtime, three times a week e. Monday, Wednesday, Friday until the warts have resolved or up to a maximum of 16 weeks. Imiquimod cream can weaken latex condoms and reduce their barrier function.
Avoid use prior to sexual activity. Actinic keratosis Imiquimod cream should be applied once daily, two times per week. Imiquimod is not funded for this indication Tip : While the manufacturer states that the sachet is for single use only, sachets are commonly used for more than one application.
The sachet can be sealed using a paper clip or tape and stored in a closed container to prevent the cream drying out. External genital warts Treatment choice for genital warts needs to be considered on an individual basis. Dosing instructions are explained in Table 1.
Actinic keratosis Imiquimod cream is one treatment option for actinic keratosis, but is not funded for this indication. Adverse effects Many adverse effects associated with imiquimod cream are the result of its therapeutic action. Systemic adverse effects and skin pigmentation changes have been reported Topical imiquimod can cause intense local inflammatory reactions.
Imiquimod; an international update on therapeutic uses in dermatology. Aldara imiquimod cream datasheet. Available from: www. Imiquimod cream Aldara for superficial basal cell carcinoma. NPS Radar December Arch Dermatol ; DermNet NZ. Systemic side effects from topical imiquimod. NZMJ ; Imiquimod cream — skin pigmentation changes and flu-like symptoms.
Prescriber Update ; 29 1 : 3. Comments There are currently no comments for this article. Make a comment:. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. There is a problem with information submitted for this request.
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